Ellen Pompeo made her major studio screen debut in Brad Silberling's Moonlight Mile (2002), starring alongside Susan Sarandon, Dustin Hoffman and Jake Gyllenhaal. She received outstanding reviews for her portrayal of an outspoken young woman carrying a silent burden that's breaking her heart.A native of Boston, Pompeo starred opposite Luke Wilson, Vince Vaughn and Will Ferrell in the wildly successful Old School (2003) and, before that, in Steven Spielberg's Catch Me If You Can (2002), opposite Leonardo DiC - www.imdb.com

When Pompeo is only 4, her mother, Kathleen, dies. The grief that her family, including five older siblings, experiences is her first childhood memory in the working-class Boston suburb of Everett, Mass. "Everyone in the house was very upset, and there was me, just knowing there was something terribly wrong," she tells Allure in 2006. "I think having my mother die at such a very young age – when she was 33 – I appreciate life so much." - www.people.com

Ellen Pompeo made her major studio screen debut in Brad Silberling’s “Moonlight Mile,” starring alongside Susan Sarandon, Dustin Hoffman and Jake Gyllenhaal. She received outstanding reviews for her portrayal of an outspoken young woman carrying a silent burden that’s breaking her heart. A native of Boston, Pompeo starred opposite Luke Wilson, Vince Vaughn and Will Ferrell in the wildly successful “Old School” and, before that, in Steven Spielberg’s “Catch Me - www.ellenpompeo.net

An overwhelming success with viewers and critics alike, this Emmy-nominated medical drama stars Ellen Pompeo (leading an ensemble cast) as Meredith Grey, a first-year surgical intern at Seattle Grace Hospital. Guided by a skillful team of dedicated doctors, Grey and her fellow interns struggle with life-and-death decisions, the pressures of a highly stressful career and the distractions of their personal lives. watch - www.tvguide.com